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Gene and Biochemical Pathway Evaluation of Burns Injury via Protein-Protein Interaction Network Analysis

Majid Rezaei-Tavirani, Vahid Mansouri, Mostafa Rezaei Tavirani, Mohammad Rostami-Nejad, Davood Bashash, Mona Zamanian Azodi

Background: Severe burns injury can affect several vital systems in the body and can cause inflammation in organs such as the heart, liver, and kidney. Many inflammatory mediators and regulatory hormones related to burn injuries are recognized. In this study, the genes related to burn injury interacted via network analysis, and the central nodes were enriched through gene ontology (GO). Materials and Methods: Disease query of STRING database was used for data gathering, and the network was constructed using Cytoscape software version 3.6.0. After gene screening, the central nodes were enriched via GO analysis by ClueGO. The highlighted genes and pathways were clustered and analyzed in detail. Results: Among 1067 genes, 35 critical genes that are involved in the 14 highlighted biochemical pathways were recognized. Interpretation of the finding indicates that a number of central genes can be considered as potential biomarkers related to burn injury. Conclusion: Can we revise to “Burn injuries have features that are common to several  diseases and increases their risk. [GMJ.2019;8:e1257] 

Burn; Gene; Biomarker; Protein-Protein Interaction Network; Biochemical Pathway

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