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Avicenna’s Concepts on Cancer Metastasis from the 11th Century

Sina Kardeh, Bahareh Kardeh

From ancient times to the era of industrialization, medical and philosophical scholars have long been wondering about the nature and the underlying mystery of cancer. Despite the extensive efforts in recent decades trying to shed light on the true histopathologic basis of malignancies, many questions remain to be elucidated. Thus, it’s not surprising that even the most notable predecessor physicians knew only very little about cancer and metastasis. In this paper, we present a brief review of the historical assumptions about the origin and spread of tumoral growths. Subsequently, we will look at an impressing notion by Avicenna about the possibility of local metastasis, which had remained unacknowledged so far and highlights the intellect of this great Persian physician even further. [GMJ.2019;8:e1292] 

Avicenna; Breast; Cancer; Metastasis

Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70.

Arnold M, Pandeya N, Byrnes G, Renehan AG, Stevens GA, Ezzati M, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 2015;16(1):36-46.

Vineis P, Wild CP. Global cancer patterns: causes and prevention. Lancet. 2014;383(9916):549-57.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87-108.


Papac RJ. Origins of cancer therapy. Yale J Biol Med. 2001;74(6):391.

MR Zimmerman. An experimental study of mummification pertinent to the antiquity of cancer. Cancer. 1977;40(3):1358-62.<1358::AID-CNCR2820400354>3.0.CO;2-J

Zheng Q, Nan K, Zheng H. Hippocrates' viewpoint on cancer. Zhonghua Yi Shi Za Zhi. 2010;40(4):234-6.

Ward JF, Eggener SE. Active surveillance monitoring: the role of novel biomarkers and imaging. Asian J Androl. 2015;17(6):882.

PMid:26112488 PMCid:PMC4814962

Zaid H, Rayan A, Said O, Saad B. Cancer treatment by Greco-Arab and Islamic herbal medicine. Open Nutra J. 2010;3:203-12.

Sudhakar A. History of Cancer, Ancient and Modern Treatment Methods. J Cancer Sci Ther. 2009;1(2):1-4.


Reedy J. Galen on cancer and related diseases. Clio Med. 1975;10(3):227-38.

Kardeh S, Choopani R, Mahmoudi Nezhad GS, Zargaran A. The Urinary Catheter and Its Significant Applications Described by Avicenna (980-1037 AD) in the Canon of Medicine. Urology. 2014;84(5):993-6.


Lu D-Y, Lu T-R, Wu H-Y, Cao S. Cancer Metastasis treatments. Current Drug Therapy. 2013;8(1):24-9.

Salmanpoor R, Saki N, Sepaskhah M, Aslani FS, Kardeh B. A metastatic cancer to skin in an otherwise asymptomatic young man: an unusual presentation. Dermatol Online J. 2013;19(10).

Weiss L. Observations on the antiquity of cancer and metastasis. Cancer Metastasis Rev. 2000;19(3):193-204.

Weiss L. Concepts of metastasis. Cancer Metastasis Rev. 2000;19(3-4):219-34.

Zargaran A, Mehdizadeh A, Zarshenas MM, Mohagheghzadeh A. Avicenna (980-1037 AD). J Neurol. 2012;259(2):389-90.


Avicenna. The Canon of Medicine. Vol.4. Translated by Sharafkandi A. Tehran: Soroush Press; 2010;388.


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