
Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?
Ahel J, Hudorović N, Višnja Vičić-Hudorović C, Nikles H. TGF-BETA in the natural history of prostate cancer. Acta Clin Croat. 2019;58(1):128-38.
https://doi.org/10.20471/acc.2019.58.01.17
PMid:31363335 PMCid:PMC6629207
DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(6):252-71.
https://doi.org/10.3322/caac.21235
PMid:24890451
Campana LG, Edhemovic I, Soden D, Perrone AM, Scarpa M, Campanacci L, et al. Electrochemotherapy-Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur J Surg Oncol. 2019;45(2):92-102.
https://doi.org/10.1016/j.ejso.2018.11.023
PMid:30528893
Ghosh S. Cisplatin: The first metal based anticancer drug. Bioorg Chem. 2019;88:102925.
https://doi.org/10.1016/j.bioorg.2019.102925
PMid:31003078
Damia G, Broggini M. Platinum Resistance in Ovarian Cancer: Role of DNA Repair. Cancers (Basel). 2019;11(1):119.
https://doi.org/10.3390/cancers11010119
PMid:30669514 PMCid:PMC6357127
Sun W, Sanderson PE, Zheng W. Drug combination therapy increases successful drug repositioning. Drug Discov Today. 2016;21(7):1189-95.
https://doi.org/10.1016/j.drudis.2016.05.015
PMid:27240777 PMCid:PMC4907866
Lin SR, Chang CH, Hsu CF, Tsai MJ, Cheng H, Leong MK, et al. Natural compounds as potential adjuvants to cancer therapy: preclinical evidence. Br J Pharmacol. 2019;177(6):1409-23.
https://doi.org/10.1111/bph.14816
PMid:31368509 PMCid:PMC7056458
Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R. Potential role of bromelain in clinical and therapeutic applications. Biomed Rep. 2016;5(3):283-8.
https://doi.org/10.3892/br.2016.720
PMid:27602208 PMCid:PMC4998156
Soheilifar S, Bidgoli M, Hooshyarfard A, Shahbazi A, Vahdatinia F, Khoshkhooie F. Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial. J Dent (Tehran). 2018;15(5):309-16.
Amini A, Masoumi-Moghaddam S, Ehteda A, Liauw W, Morris DL. Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells. Am J Cancer Res. 2016;6(2):350-69.
Tysnes BB, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F. Bromelain reversibly inhibits invasive properties of glioma cells. Neoplasia. 2001;3(6):469-79.
https://doi.org/10.1038/sj.neo.7900196
PMid:11774029 PMCid:PMC1506565
Pauzi AZ, Yeap SK, Abu N, Lim KL, Omar AR, Aziz SA, et al. Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro. Chin Med. 2016;11:46.
https://doi.org/10.1186/s13020-016-0118-5
PMid:27891174 PMCid:PMC5111264
Satari A, Amini AS, Raeisi E, Lemoigne Y, Hiedarian E. Synergetic impact of combined 5-fluorouracil and rutin on apoptosis in pc3 cancer cells through the modulation of p53 gene expression. Adv Pharm Bull. 2019;9(3):462-9.
https://doi.org/10.15171/apb.2019.055
PMid:31592435 PMCid:PMC6773939
Raeisi F, Shahbazi-Gahrouei D, Raeisi E, Heidarian E. Evaluation of the radiosensitizing potency of bromelain for radiation therapy of 4T1 breast cancer cells. J Med Signals Sens. 2019;9(1):68-74.
https://doi.org/10.4103/jmss.JMSS_25_18
PMid:30967992 PMCid:PMC6419564
Groeben C, Wirth MP. Prostate cancer: Basics on clinical appearance, diagnostics and treatment. Med Monatsschr Pharm. 2017;40(5):192-201.
Kalra N, Bhui K, Roy P, Srivastava S, George J, Prasad S, et al. Regulation of p53,nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin. Toxicol Appl Pharmacol. 2008;226(1):30-7.
https://doi.org/10.1016/j.taap.2007.08.012
PMid:17889918
Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol. 2005;205(2):275-92.
https://doi.org/10.1002/path.1706
PMid:15641020
Oun R, Moussa YE, Wheate NJ. The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans. 2018;47(19):6645-53.
https://doi.org/10.1039/C8DT00838H
PMid:29632935
Hoseinzadeh S, Raeisi E, Lemoigne Y, Heidarian E. Effects of combined 5-Fluorouracil and ZnO NPs on human breast cancer MCF-7 Cells: P53 gene expression, Bcl-2 signaling pathway, and invasion activity. Nanomed J. 2019;6(3):232-40.
Wei Y, Yang P, Cao S, Zhao L. The combination of curcumin and 5-fluorouracil in cancer therapy. Arch Pharm Res. 2018;41(1):1-13.
https://doi.org/10.1007/s12272-017-0979-x
PMid:29230689
Alaufi OM, Noorwali A, Zahran F, Al-Abd AM, Al-Attas S. Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro. Sci Rep. 2017;17(1):13131.
https://doi.org/10.1038/s41598-017-13357-5
PMid:29030590 PMCid:PMC5640598
Chobotova K, Vernallis A, Majid FA. Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives. Cancer Lett. 2010;290(2):148-56.
https://doi.org/10.1016/j.canlet.2009.08.001
PMid:19700238
Bhatnagar P, Pant AB, Shukla Y, Chaudhari B, Kumar P, Gupta KC. Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model. Eur J Pharm Biopharm. 2015;91:35-46.
https://doi.org/10.1016/j.ejpb.2015.01.015
PMid:25619920
Secor ER Jr, Szczepanek SM, Castater CA, Adami AJ, Matson AP, Rafti ET, et al. Bromelain inhibits allergic sensitization and murine asthma via modulation of dendritic cells. Evid Based Complement Alternat Med. 2013;2013:702196.
https://doi.org/10.1155/2013/702196
PMid:24381635 PMCid:PMC3870104
Fitzhugh DJ, Shan S, Dewhirst MW, Hale LP. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol. 2008;128(1):66-74.
https://doi.org/10.1016/j.clim.2008.02.015
PMid:18482869 PMCid:PMC2516972
Ghensi P, Cucchi A, Bonaccorso A, Ferroni L, Gardin C, Mortellaro C, et al. In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells. J Craniofac Surg. 2019;30(4):1064-7.
https://doi.org/10.1097/SCS.0000000000004862
PMid:30358745
Chang TC, Wei PL, Makondi PT, Chen WT, Huang CY, Chang YJ. Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy. PLoS One. 2019;14(1):e0210274.
https://doi.org/10.1371/journal.pone.0210274
PMid:30657763 PMCid:PMC6338369
Baez R, Lopes MT, Salas CE, Hernandez M. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Planta Med. 2007;73(13):1377-83.
https://doi.org/10.1055/s-2007-990221
PMid:17893836
Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, et al. Bromelain-induced apoptosis in GI-101A breast cancer cells. J Med Food. 2012;15(4):344-9.
https://doi.org/10.1089/jmf.2011.0145
PMid:22191568
Gläser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets. 2006;17(1):37-41.
https://doi.org/10.1080/09537100500197489
PMid:16308185
Amini A, Ehteda A, Masoumi Moghaddam S, Akhter J, Pillai K, Morris DL. Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). Onco Targets Ther. 2013;6:403-9.
https://doi.org/10.2147/OTT.S43072
PMid:23620673 PMCid:PMC3633552
Pillai K, Ehteda A, Akhter J, Chua TC, Morris DL. Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells. Anticancer Drugs. 2014;25(2):150-60.
https://doi.org/10.1097/CAD.0000000000000039
PMid:24366282
Nasiri R, Almaki JH, Idris A, Nasiri M, Irfan M, Majid FA. Targeted delivery of bromelain using dual mode nanoparticles: Synthesis, physicochemical characterization, in vitro and in vivo evaluation. RSC Adv. 2017;7:40074‑94.
https://doi.org/10.1039/C7RA06389J
Bendale Y, Bendale V, Paul S. Evaluation of cytotoxic activity of platinum nanoparticles against normal and cancer cells and its anticancer potential through induction of apoptosis. Integr Med Res. 2017;6(2):141-8.
https://doi.org/10.1016/j.imr.2017.01.006
PMid:28664137 PMCid:PMC5478255
Bhui K, Prasad S, George J, Shukla Y. Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway. Cancer Lett. 2009;282(2):167-76.
https://doi.org/10.1016/j.canlet.2009.03.003
PMid:19339108
Amini A, Masoumi-Moghaddam S, Ehteda A, Morris DL. Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy. J Exp Clin Cancer Res. 2014;33(1):92.
https://doi.org/10.1186/PREACCEPT-1557435139144520
Chaudhary B, Bist R. Protective manifestation of bacoside A and bromelain in terms of cholinesterases, gamma-amino butyric acid, serotonin level and stress proteins in the brain of dichlorvos-intoxicated mice. Cell Stress Chaperones. 2017;22(3):371-6.
https://doi.org/10.1007/s12192-017-0773-1
PMid:28321764 PMCid:PMC5425367
Refbacks
- There are currently no refbacks.