Cover Image

Uterine Myxoid Leiomyosarcoma with Stromal Chondroid Metaplasia: A Rare Case Report

Fatemeh Sari Aslani, Negar Taheri, Fatemehsadat Najib, Mojgan Akbarzadeh-Jahromi
Background: Uterine leiomyosarcoma is a rare gynecological disease. Myxoid leiomyosarcoma (mLMS) is an aggressive and very uncommon type of leiomyosarcoma, with few cases reported in English literature. Stromal metaplasia is rare in leiomyosarcoma. Here we present huge uterine myxoid leiomyosarcoma with stromal chondroid metaplasia. Case Report: A 48–year–old single woman with lower abdominal pain and increased abdominal circumference. The detected mass on imaging was diagnosed as uterine mLMS with stromal chondroid metaplasia in the histopathological examination after surgery. Conclusion: Myxoid leiomyosarcoma should be considered in uterine mass with extensive myxoid change, infiltrative border, low mitotic count, and mild atypia. Stromal chondroid metaplasia can be seen in the myxoid leiomyosarcoma. [GMJ.2021;10:e1817]
Myxoid Leiomyosarcoma; Leiomyosarcoma; Metaplasia; Uterus
PDF EPUB HTML

King ME, Dickersin GR , Scully RE. Myxoid leiomyosarcoma of the uterus. A report of six cases. Am J Surg Pathol. 1982;6(7):589-598.

https://doi.org/10.1097/00000478-198210000-00001

PMid:7180961

Ip PP , Cheung AN. Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential. Best Pract Res Clin Obstet Gynaecol. 2011;25(6):691-704.

https://doi.org/10.1016/j.bpobgyn.2011.07.003

PMid:21865091

Parra-Herran C, Schoolmeester JK, Yuan L, et al. Myxoid Leiomyosarcoma of the Uterus. AM J SURG PATHOL. 2016;40(3):285-301.

https://doi.org/10.1097/PAS.0000000000000593

PMid:26866354

Verma M, Joseph G , McCluggage WG. Uterine composite tumor composed of leiomyosarcoma and embryonal rhabdomyosarcoma with immature cartilage. Int J Gynecol Pathol.. 2009;28(4):338-342.

https://doi.org/10.1097/PGP.0b013e3181942a4f

PMid:19483631

Kotru M, Gupta R, Aggarwal S, Sharma S , Bhatia A. Cartilaginous metaplasia in uterine leiomyoma. Arch Gynecol Obstet. 2009;280(4):671-673.

https://doi.org/10.1007/s00404-009-0970-y

PMid:19225797

D'Angelo E , Prat J. Uterine sarcomas: a review. Gynecol Oncol. 2010;116(1):131-139.

https://doi.org/10.1016/j.ygyno.2009.09.023

PMid:19853898

Cruz M, Murakami T, Tsuda K, et al. Myxoid leiomyoma of the uterus: CT and MRI features. Abdom Imaging. 2001;26(1):98-101.

https://doi.org/10.1007/s002610000102

PMid:11116372

Chen X, Arend R, Hamele-Bena D, et al. Uterine carcinosarcomas: clinical, histopathologic and immunohistochemical characteristics. Int J Gynecol Pathol. 2017;36(5):412-419.

https://doi.org/10.1097/PGP.0000000000000346

PMid:28700424

Matsuda M, Ichimura T, Kasai M, et al. Preoperative diagnosis of usual leiomyoma, atypical leiomyoma, and leiomyosarcoma. Sarcoma. 2014;2014.

https://doi.org/10.1155/2014/498682

PMid:25400500 PMCid:PMC4221903

Prat J. Uterine sarcomas. Int J Gynaecol Obstet. 2015;131(S2). doi: 10.1016/j.ijgo.2015.06.006.

https://doi.org/10.1016/j.ijgo.2015.06.006

PMid:26433666

Parra-Herran C. Myxoid Mesenchymal Tumors of the Uterus: An Update on Classification, Definitions, and Differential Diagnosis. Adv Anat Pathol. 2017;24(6):354-361.

https://doi.org/10.1097/PAP.0000000000000164

PMid:28787279

Willems SM, Wiweger M, van Roggen JFG , Hogendoorn PC. Running GAGs: myxoid matrix in tumor pathology revisited. Virchows Archiv. 2010;456(2):181-192.

https://doi.org/10.1007/s00428-009-0822-y

PMid:19705152 PMCid:PMC2828560

Fuehrer NE, Keeney GL, Ketterling RP, Knudson RA , Bell DA. ALK-1 protein expression and ALK gene rearrangements aid in the diagnosis of inflammatory myofibroblastic tumors of the female genital tract. Arch Pathol Lab Med. 2012;136(6):623-626.

https://doi.org/10.5858/arpa.2011-0341-OA

PMid:22646268

Kasashima S, Kobayashi M, Yamada M , Oda Y. Myxoid endometrial stromal sarcoma of the uterus. Pathol Int. 2003;53(9):637-641.

https://doi.org/10.1046/j.1440-1827.2003.01525.x

PMid:14507323

Burch DM , Tavassoli FA. Myxoid leiomyosarcoma of the uterus. Histopathology. 2011;59(6):1144-1155.

https://doi.org/10.1111/j.1365-2559.2011.04053.x

PMid:22175894

Canter RJ, Martinez SR, Tamurian RM, et al. Radiographic and histologic response to neoadjuvant radiotherapy in patients with soft tissue sarcoma. Ann Surg Oncol. 2010;17(10):2578-2584.

https://doi.org/10.1245/s10434-010-1156-3

PMid:20556523 PMCid:PMC2941714

DOI: http://dx.doi.org/10.31661/gmj.v10i0.1817

Refbacks

  • There are currently no refbacks.