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Evaluation of Morphological Changes in Breast Cancer: Influence of Fractal Meta-Analysis

SeyedAbbas Mirmalek, Niloofar sadat Yarandi, Mohammad Tafazoli Shadpour, Minoo Saatian, Homa Raeesi, Esmaieel Jafargholi Rangraz, Masoud Salehi, Seyed Alireza Salimi Tabatabaee

Many studies suggested that fractals could be brought in any structural anarchy, such as cancers, for diagnosis and prognosis evaluation by quantifying it and expressing it in terms of fractal geometry. In this study, we aimed to evaluate pathologic grades or breast carcinomas by fractal analysis. This cross-sectional study was performed on 60 women with breast ductal carcinoma. From all the patients some photographs from the smears with pathological standard and with a digital camera were taken to analyze them by MATLAB software via Box-Counting method. The used analytical methods were ANOVA and T tests. There was a significant association between fractal count and the pathological grade (P<0.05). According to the findings of this study, fractal count was a prognostic indicator in breast cancer patients. However, we recommended performing further studies with higher sample size and in other types of cancers.

Breast Cancer; Fractal Complex; Ductal Carcinoma; Prediction

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009; 59(4): 225-49.

Qaseem A, Snow V, Sherif K, Aronson M, Weiss KB, Owens DK. Screening mammography for women 40 to 49 years of age: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2007; 146(7): 511-5.

Smigal C, Jemal A, Ward E, et al. Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin. 2006; 56(3): 168-83.

Humphrey LL, Helfand M, Chan BK, Woolf SH. Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2002; 137(5 Part 1): 347-60.

Vahabi M. Breast cancer screening methods: a review of the evidence. Health Care Women Int. 2003; 24(9): 773-93.

Gail MH, Costantino JP, Pee D, et al. Projecting individualized absolute invasive breast cancer risk in African American women. J Natl Cancer Inst. 2007; 99(23): 1782-92.

Nguyen T, Rangayyan R. Shape Analysis of Breast Masses in Mammograms via the Fractal Dimension. Conf Proc IEEE Eng Med Biol Soc. 2005; 3: 3210-3.

Dey P, Mohanty SK. Fractal dimensions of breast lesions on cytology smears. Diagn Cytopathol. 2003; 29(2): 85-6.

Li H, Giger ML, Olopade OI, Lan L. Fractal analysis of mammographic parenchymal patterns in breast cancer risk assessment. Acad Radiol. 2007; 14(5): 513-21.

Crişan DA, Lesaru M, Dobrescu R, Vasilescu C. Fractal analysis in the diagnosis of breast tumors. Chirurgia (Bucur). 2007; 102(1): 27-30.

Krasowska M, Grzywna ZJ, Mycielska ME, Djamgoz MB. Fractal analysis and ionic dependence of endocytotic membrane activity of human breast cancer cells. Eur Biophys J. 2009; 38(8): 1115-25.

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