Change in Programmed Death-1 And Inducible Costimulator Expression in Patients with Acute Myeloid Leukemia Following Chemotherapy and Its Cytogenetic Abnormalities

  • Mahdiyar Iravani Saadi Pediatric Cell and Gene Therapy Research Center, Gene, Cell and TissueResearch Institute ,Tehran University of Medical Sciences, Tehran, Iran / Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Maryam Ahmadyan Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Heeva Jalali Department of Animal Science, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran https://orcid.org/0000-0002-6473-1772
  • Nasrin Noshadi Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mitra Moradi Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Fatemeh Mardani Valandani Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nadiya Kheradmand Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Hossain Ali Rostamipour Department of Internal Medicine, Jahrom University of medical sciences, Jahrom, Iran
  • Fakhroddin Hosseini Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Amir Ali Hamidieh Pediatric Cell and Gene Therapy Research Center, Gene, Cell and TissueResearch Institute ,Tehran University of Medical Sciences, Tehran, Iran
  • Abolfazl Khalafi-Nezhad 5 Hematology, Oncology and Bone Marrow Transplantation Department, Shiraz University of Medical Sciences, Shiraz, Iran
Keywords: Acute Myeloid Leukemia, Programmed Death, Inducible Costimulator, Induction Therapy, Mononuclear Cells

Abstract

Background: Programmed death-1 (PD-1) and inducible costimulator (ICOS) are immune checkpoint receptors participating in tumor immune evasion, which counters the activation signal provided through the T-cell receptor ligation. This study aimed to investigate the relationship between the expression of PD-1 and ICOS on mononuclear cells (MNCs) isolated from the peripheral blood of acute myeloid leukemia (AML) patients and their response to induction chemotherapy. Materials and Methods: Peripheral blood samples (5cc) were collected from 56 AML patients at first diagnosis before and after the induction therapy regimen for AML. PD-1 and ICOS expression were analyzed in all patients before and after the standard induction therapy regimen. Results: The expression of PD-1 and ICOS significantly decreased (66.7 and 16.3 fold, respectively) in AML patients following chemotherapy compared to its baseline value (P=0.01 and P=0.001, respectively). The expressions of PD-1 and ICOS were significantly different between favorable and poor risk groups. Conclusions: Lower PD-1 and ICOS expressions on the surface of MNCs before induction therapy were associated with a better response to treatments. In addition, PD-1 and ICOS expression on MNCs decreased after induction therapy.

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Published
2022-12-31
How to Cite
Iravani Saadi, M., Ahmadyan, M., Jalali, H., Noshadi, N., Moradi, M., Mardani Valandani , F., Kheradmand, N., Rostamipour , H. A., Hosseini , F., Hamidieh , A. A., & Khalafi-Nezhad, A. (2022). Change in Programmed Death-1 And Inducible Costimulator Expression in Patients with Acute Myeloid Leukemia Following Chemotherapy and Its Cytogenetic Abnormalities. Galen Medical Journal, 11, e2394. https://doi.org/10.31661/gmj.v11i.2394
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Original Article