The Therapeutic Effect of Mesenchymal Stem Cells in Spinal Cord Injury

  • Sohrab Negargar Cardiovascular Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Marziyeh Pooladi Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Fariba Hatami Nazaja Health Relief and Treatment Department, Army of the Islamic Republic of Iran, Tehran, Iran
  • Seyed Shahabeddin Bahrani Nursing and Midwifery School, Hamadan University of Medical Sciences, Hamadan, Iran
  • Hossein Kargar Jahromi Research Center for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran; Faculty Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran
Keywords: Bone Marrow, Mesenchymal Stem Cells, Spinal Cord Injuries, Umbilical Cord, Adipose Tissue

Abstract

Spinal cord injury (SCI) is an injury of the spine that could be life-threatening and lead to partial or complete loss of autonomic, sensory, and motor function below the injured area. Surgery decompression and steroid injection are the current treatments for SCI, but neither is particularly effective, and there is a growing demand for a more potent treatment. Mesenchymal stem cells (MSCs) are novel therapeutic agents that were used in different inflammatory diseases. These cells have immunomodulatory and regenerative properties which make them a promising candidate for neurological disorders such as SCI. MSCs are easily expandable in vitro and have the capacity for multilineage differentiation. These cells, which can be derived from adipose tissue, bone marrow (BM), Wharton jelly, or umbilical cord, have immunomodulatory and paracrine capabilities. They can release a variety of cytokines and other substances that suppress the growth of B cells, T cells, and natural killer cells (NKCs) as well as alter the activity of dendritic cells (DCs). In this study, we reviewed clinical studies that showed the effects of MSCs from different sources in the SCI.

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Published
2022-12-10
How to Cite
Negargar, S., Pooladi, M., Hatami, F., Bahrani, S. S., & Kargar Jahromi, H. (2022). The Therapeutic Effect of Mesenchymal Stem Cells in Spinal Cord Injury. Galen Medical Journal, 11, e2541. https://doi.org/10.31661/gmj.v11i.2541
Section
Review Article