Herbal Treatment of Oligomenorrhea with Sesamum indicum L.: A Randomized Controlled Trial

  • Maryam Yavari
  • Safoura Rouholamin
  • Mojgan Tansaz
  • Somayeh Esmaeili
Keywords: Oligomenorrhea, Sesamum indicum, Progesterone, Menstruation


Background: Oligomenorrhea (defined as infrequent menstrual flow at intervals of 36 days to 6 months or 5–7 cycles in a year) is mostly managed with hormone therapy; however, there is an increasing demand for alternative medicine treatments in this field. This study is designed to evaluate the efficacy of Sesamum indicum L. in inducing menstrual bleeding in women with oligomenorrhea. Materials and Methods: A single-blind clinical trial was performed on 56 cases of oligomenorrhea, admitted to Beheshti hospital clinic. Patients randomly received treatment for a week either in the sesame or progesterone group and then were followed for 8 weeks. Menstrual bleeding occurrence, waiting period, volume of blood flow, severity of pain, uterus temperament, menstruation in the next episode and side effects were assessed by interview. Results: Twenty-seven patients (mean age 29.42 ± 8.99 years) and 29 patients (mean age 26.63±5.63 years) were enrolled in the sesame and progesterone groups, respectively. Seventy and two percent and 93.10% of the patients in the sesame and progesterone groups experienced menstrual bleeding (P=0.012) on an average of 10.38 and 11.88 days (P>0.05) respectively. Volume of blood flow and severity of pain were not increased in both groups. Fifty percent and 6% of the patients in the sesame and progesterone groups experienced on-time menstruation in the next (drug-free) episode of menstruation, respectively (P= 0.016).Conclusion: Although the rate of bleeding following sesame consumption was lower than progesterone-treated group, it seems that the response rate is high enough to suggest more assessments in the future; moreover, in the sesame group, the rate of menstruation in the next drug-free episode was significantly higher than the progesterone group. Therefore, sesame, as a well-tolerated, partially effective choice in inducing and maintaining regular bleeding, could be considered in the patients who are not suitable candidates for hormone therapy.[GMJ.2016;5(3):114-121]


Panay N, Pritsch M, Alt J. Cyclical dydrogesterone in secondary amenorrhea: results of a double-blind, placebo-controlled, randomized study. Gynecol Endocrinol 2007; 23(11):611–8.

Amato MC, Verghi M, Galluzzo A, Giordano C. The oligomenorrhoic phenotypes of polycystic ovary syndrome are characterized by a high visceral adiposity index: a likely condition of cardiometabolic risk. Human Reproduction 2011;der088.

Tehrani FR, Simbar M, Tohidi M, Hosseinpanah F, Azizi F. The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study. Reproductive Biology and Endocrinology 2011; 9(1):1.

Li S, He A, Yang J, Yin T, Xu W.A logistic regression analysis of factors related to the treatment compliance of infertile patients with polycystic ovary syndrome. J Reprod Med 2011; 56(7-8):325-32.

Tansaz M, Mokaberinejad R, Bioos S, Sohrabvand F, Emtiazy M. Avicenna aspect of premature ovarian failure. Iranian Journal of Reproductive Medicine 2013;11(2):167-8.

Razi Mohammad ibn z. Alhavi. Tehran: The Institute for Medical History- Islamic and Complementary Medicine, Tehran University of Medical Sciences 2010.

Aqili Khorasani MH: Makhzan al adviah. Tehran: Safa Publication; 1992.

Ibn-e-sina (Avicenna Husain): Al-Qanun fit-tib [The Canon of Medicine] (research of ebrahim shamsedine). Beirut: Alaalami Beirut library Press; 2005.

Heravi MS: Qarabadin Salehi. Tehran: Iran University of Medical Sciences, Institute of history of Medicine studies and Islamic medicine; 2005.

Aquili Khorasani MH: Qarabadin Kabir. Tehran: Irani University of Medical Sciences, Institute of hystory of Medicine studies and Islamic medicine; 2005.

Momen Tonekaboni M: Tohfe Momenin. Tehran: Shahid Beheshty University of Medical Sciences, Institute of history of Medicine studies and Islamic medicine; 2005.

Borchani C, Besbes S, Blecker C, Attia H. Chemical characteristics and oxidative stability of sesame seed, sesame paste, and olive oils. Journal of Agricultural Science and Technology 2010; 12:585-96.

Rangkadilok N, Pholphana N, Mahidol C, Wongyai W, Saengsooksree K, Nookabkaew S, et al. Variation of sesamin, sesamolin and tocopherols in sesame (Sesamum indicum L.) seeds and oil products in Thailand. Food Chemistry 2010; 122(3):724-30.

Wu WH, Kang YP, Wang NH, Jou HJ, Wang TA. Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. J Nutr 2006; 136(5):1270-5.

Ghasemi dehkordi N: Iran pharmacopeia. Iran pharmacopeia writers’ committee. Tehran: Ministry of health, treatment and education publication, Food and drug institute;2002.

Tansaz M, Sohrabvand F, Adhami S, Keshavarz M, Hashem Dabaghian F, Bioos S, et al. Design and Validation of an Instrument for uterine temperament detection and evaluation of uterine temperament in Iranian infertile women, submitted 2016.

Yavari M, Rouholamin S, Tansaz M, Bioos S, Esmaeili S. Sesame a Treatment of Menstrual Bleeding Cessation in Iranian Traditional Medicine: Results from a Pilot Study. Shiraz e med J 2014; 15(3): e21893.

Chen X, Ni R, Mo Y, Li L, Yang D. Appropriate BMI levels for PCOS patients in Southern China. Human reproduction 2010; 25(5):1295-302.

Legro RS. Obesity and PCOS: implications for diagnosis and treatment. In Seminars in reproductive medicine 2012; 30(06):496-506).

Baqai Z, Khanam M, Parveen S. prevalence of PCOS in infertile patients. Medical channel 2010; 16(3).

Papadakis EN, Lazarou D, Grougnet R. Effect of the form of the sesame-based diet on the absorption of the lignans. Br J Nutr 2008; 100:1213-19.

Anagnostis A, Papadopoulos AI. Effects of a diet rich in sesame (Sesamum indicum) pericarp on the expression of estrogen receptor alpha and estrogen receptor beta in rat prostate and uterus. Br J Nutr 2009; 102(5):703-8.

Amini Mahabadi J, Hassani Bafrani H, Nikzad H, Taherian A, Eskandarinasab M, Shaheir M. Effect of a sesame seed regimen on the adult rat testicular structure. KAUMS Journal ( FEYZ ) 2012; 16(4):304-10.

Asghary S, Shirzad H, Heidarian E, Mirhosseini M, Ansari R, Shahinfard N, et al. Effects of Sesamum indicum L. on fibrinogen and factor 7 in hypercholesterolemic rabbits. J Shahrekord Univ Med Sci 2011; 13(1):21-6.

Moran LJ, Hutchison SK, Meyer C, Zoungas S, Teede HJ. A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome. Clin Sci (Lond) 2009;116:761-770.

Rajendran S, Willoughby SR, Chan WP, Liberts EA, Heresztyn T, Saha M, et al. Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects. Atherosclerosis 2009; 204:509-14.

Atiomo WU, Fox R, Condon JE, Shaw S, Friend J, Prentice AG, et al. Raised plasminogen activator inhibitor-1 (PAI-1) is not an independent risk factor in the polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 2000; 52:487-92.

Mannerås-Holm L, Baghaei F, Holm G, Janson PO, Ohlsson C, Lönn M, et al. Coagulation and fibrinolytic disturbances in women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism 2011;96(4):1068-76.

Mokaberinejad R, Zafarghandi N, Bioos S, Dabaghian FH, Naseri M, Kamalinejad M, et al. Mentha longifolia syrup in secondary amenorrhea: a double-blind, placebo-controlled, randomized trials. Daru 2012; 20(1):97.

Braden BB, Garcia AN, Mennenga SE, Prokai L, Villa SR, Acosta JI, et al. Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time. Psychopharmacology 2011; 218(2):405-18.

Huijbregts RP, Michel KG, Hel Z. Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs. Contraception 2014; 90(2):123-9.

How to Cite
Yavari, M., Rouholamin, S., Tansaz, M., & Esmaeili, S. (2016). Herbal Treatment of Oligomenorrhea with Sesamum indicum L.: A Randomized Controlled Trial. Galen Medical Journal, 5(3), 114-21. https://doi.org/10.31661/gmj.v5i3.613
Original Article